Impact Performance of Pharmaceutical Tablets
Common pharmaceutical pills and tablets are usually finished with a coating to facilitate swallowing, time phased release of the medication, identification and branding. Coatings may also help ensure long shelf life by protecting the underlying product from negative environmental conditions such as light, temperature, moisture and mechanical loading. Particularly in the manufacturing and packaging process, tablet coatings are subject to impacts that can cause damage.
Impact testing can deliver value to the manufacturer in the form of performance data for research and development of new coating materials or processes. Once a suitable product has been established, a manufacturer can implement a quality control program utilizing baseline data from an impact performance test to provide ongoing process validation.
An Instron Dynatup Mini Tower, instrumented with a low load Piezo Sensor Tup, ½ inch hemispherical tup insert, and Impulse Data Acquisition and Analysis System are ideal for the testing of pharmaceutical pills and tablets. For fixturing we recommend using a stiff, flat, metal plate which can be secured to the table area of the Mini Tower using the four clamps that are available. Using the Ultra Lightweight Crosshead and varying the impact energies by varying the drop height pills and tablets can be tested until the show no sign of failure.
This impact test solution is well suited for determining the impact performance characteristics of pharmaceutical tablets, such as lot consistency and failure or incipient damage points. These characteristics may in turn be related to the coating material used on the product. By understanding how the coating may strengthen or weaken the pills, changes to improve the product can be made.
Impact resistance is one of the most important properties for component designers to consider, as well as the most difficult to quantify. Impact resistance is a critical measure of service life and more importantly these days, it involves the perplexing problem of product safety and liability. With the combined experience of Dynatup® and CEAST, Instron® has more than 80 years experience in designing impact testing systems to simulate real-life impact conditions.
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